Differences in Photic Entrainment of Circadian Locomotor Activity Between Lean and Obese Volcano Mice (Neotomodon alstoni)

Authors

Manuel Miranda-Anaya Unidad Multidisciplinaria de Docencia e Investigación, Juriquilla, Qro, Facultad de Ciencias, Universidad Nacional Autónoma de México
Dalia Luna-Moreno CONACYT-Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Juriquilla, Qro
Agustín Carmona-Castro Departamento de Biología Celular, Facultad de Ciencias, Ciudad Universitaria, Universidad Nacional Autónoma de México, Ciudad de México
Mauricio Díaz-Muñoz Universidad Nacional Autónoma de MéxicoInstituto de Neurobiología, Universidad Nacional Autónoma de México, Juriquilla, Qro

DOI:

Keywords:

Circadian, Photic phase shift, Obesity, Locomotor activity, Neotomodon alstoni, c-Fos, VIP

Abstract

Obesity is a growing problem worldwide with a clear impact on health status. It is also a condition that negatively affects circadian rhythms. When the mouse Neotomodon alstoni is fed a regular rodent chow, some individuals develop obesity, representing an opportunity to compare the effects of spontaneous obesity upon the circadian organization in this species with that observed in other rodents with induced obesity. We report differences in the free running circadian locomotor activity rhythm and in the effects of light pulses between lean and obese mice. Also, the photo-induced expression of the c-Fos protein and vasoactive intestinal peptide (VIP) in the suprachiasmatic nucleus (SCN) were examined at circadian time (CT) 14 and 22. We show that obese mice have a larger dispersion of the period of circadian locomotor rhythm in constant darkness. Photic induced phase shifts are nearly 50% shorter at CT 14, and 50% larger at CT 22 than in lean mice. The photoinduction of VIP in the SCN at CT 22 was larger in obese mice, which may be related to the differences observed in photic phase shifting. Our work indicates that the obesity in Neotomodon has effects on the neural mechanisms that regulate the circadian system.

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Published

2017-01-27

Issue

Vol. 15 (2017)

Section

Research Article

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